Crash 3. A new international effort in the management of traumatic hemorrhagic brain damage.

نویسندگان

  • M A Muñoz-Sánchez
  • J J Egea-Guerrero
  • F Murillo-Cabezas
چکیده

Despite the advances in recent decades in the monitorization, diagnosis and treatment of severe traumatic brain injury (STBI), and which have reduced mortality in the developed countries, 50% of all patients admitted to hospital due to STBI continue to suffer significant life-long sequelae. The probability of death or of sequelae is largely dependent upon the amount of brain tissue destroyed, and this in turn is conditioned by the extent of the primary damage resulting from the magnitude of the biomechanical impact and by the different causes of secondary brain lesions which inexorably worsen the outcome. Hemorrhagic lesions, in the form of intraaxial hematomas or extraaxial hematomas, are found in 50% of all STBIs and have a strong impact upon the outcome. In general, extraaxial lesions, specifically subdural hematomas and epidural hematomas, are identified from the first computed tomography (CT) scan after the traumatism, tend to be unilateral, and are mostly amenable to surgical drainage. In contrast, intraaxial lesions, in the form of intraparenchymal hematomas or hemorrhagic contusions, can be multiple,

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Validation of CRASH Model in Prediction of 14-Day Mortality and 6-Month Unfavourable Outcome of Pediatric Traumatic Brain Injury

Background: Value of Corticosteroid Randomisation after Significant Head Injury (CRASH) prognostic model has not been assessed in children with traumatic brain injury (TBI). This study is designed to examine the value of CRASH model in prediction of 14-day mortality and 6-month unfavourable outcome of pediatric TBI. Materials and Methods: </stron...

متن کامل

ECG changes of cardiac origin in elderly patients with traumatic brain injury

Background: Simultaneous electrocardiographic (ECG) changes are seen in hemorrhagic brain events even in the absence of associated myocardial infarction (MI). This study was designed to assess the role of ECG changes to predict true MI in patients with hemorrhagic brain trauma. Methods: Data of 153 patients with traumatic brain injury and concomitant ECG changes were recorded. Enzyme study w...

متن کامل

A nested mechanistic sub-study into the effect of tranexamic acid versus placebo on intracranial haemorrhage and cerebral ischaemia in isolated traumatic brain injury: study protocol for a randomised controlled trial (CRASH-3 Trial Intracranial Bleeding Mechanistic Sub-Study [CRASH-3 IBMS])

BACKGROUND Tranexamic acid prevents blood clots from breaking down and reduces bleeding. However, it is uncertain whether tranexamic acid is effective in traumatic brain injury. The CRASH-3 trial is a randomised controlled trial that will examine the effect of tranexamic acid (versus placebo) on death and disability in 13,000 patients with traumatic brain injury. The CRASH-3 trial hypothesizes ...

متن کامل

Traumatic hemorrhagic shock: advances in fluid management.

A number of concerns have been raised regarding the advisability of the classic principles of aggressive crystalloid resuscitation in traumatic hemorrhagic shock. This issue reviews the advances that have led to a shift in the emergency department (ED) protocols in resuscitation from shock state, including recent literature regarding the new paradigm for the treatment of traumatic hemorrhagic s...

متن کامل

O14: Application of Neural Stem Cells Derived from Human Meningioma in Traumatic Brain Injury

Traumatic brain injury is considered as one of the main causes of morbidity and mortality worldwide. Apart from primary mechanical injury, Secondary injuries due to inflammation and apoptosis result in great neuronal damage. Current treatments are not able to regenerate the damaged part and prevent future sequels. Using human stem cells with self-assembling scaffolds may be promising in treatme...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Medicina intensiva

دوره 36 8  شماره 

صفحات  -

تاریخ انتشار 2012